Recombinant Human Synaptophysin (SYP)

Uniprot Id

P08247

Target Species

Human

Target Name

SYP

Target Full Name

Synaptophysin

Target Function

Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity.

Target Involvement

Mental retardation, X-linked 96 (MRX96)

Target Subcellular Location

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.

Target Protein Families

Synaptophysin/synaptobrevin family

Target Tissue Specificity

Expressed in the brain, with expression in the hippocampus, the neuropil in the dentate gyrus, where expression is higher in the outer half of the molecular layer than in the inner half, and in the neuropil of CA4 and CA3.

Target Research Area

Neuroscience

Target Synonyms

SYP; Synaptophysin; Major synaptic vesicle protein p38

Target Background

This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with an X-linked form of cognitive disability.