Recombinant Human Tachykinin-3 (TAC3)

Uniprot Id

Q9UHF0

Target Species

Human

Target Name

TAC3

Target Full Name

Tachykinin-3

Target Function

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Is a critical central regulator of gonadal function.

Target Involvement

Hypogonadotropic hypogonadism 10 with or without anosmia (HH10)

Target Subcellular Location

Secreted.

Target Protein Families

Tachykinin family

Target Synonyms

Gamma tachykinin 3; Neurokinin B; Neurokinin B like protein; Neurokinin B protein; Neurokinin beta; Neurokinin-B; NeurokininB; Neuromedin K; Neuromedin-K; NeuromedinK; NKB; NKNB ; Preprotachykinin B; PreprotachykininB; PRO 1155; PRO1155 ; TAC 3; TAC3; Tachykinin 3; Tachykinin3; TKNK_HUMAN; ZNEUROK 1; ZNEUROK1

Target Background

This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. This peptide is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.