Recombinant Human Target of Nesh-SH3 (ABI3BP), Truncated

Uniprot Id

Q7Z7G0

Target Species

Human

Target Name

ABI3BP

Target Full Name

Target of Nesh-SH3

Target Involvement

Defects in ABI3BP has been found in a patient with isolated coloboma, a defect of the eye characterized by the absence of ocular structures due to abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Isolated colobomas may be associated with an abnormally small eye (microphthalmia) or small cornea.

Target Subcellular Location

Secreted.

Target Tissue Specificity

Expressed in brain, heart, lung, liver, pancreas kidney and placenta.

Target Synonyms

ABI gene family member 3 (NESH) binding protein; ABI gene family member 3 binding protein; ABI gene family member 3-binding protein; ABI3BP; FLJ41743; FLJ41754; Nesh binding protein; Nesh BP; Nesh-binding protein; NeshBP; Target of Nesh SH3; Target of Nesh-SH3; Tarsh; TARSH_HUMAN

Target Background

Predicted to enable actin filament binding activity and glycosaminoglycan binding activity. Predicted to be involved in regulation of actin cytoskeleton reorganization; regulation of dendritic spine morphogenesis; and regulation of postsynaptic density assembly. Predicted to act upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Located in extracellular space. Colocalizes with collagen-containing extracellular matrix.