Recombinant Human Telomere length regulation protein TEL2 homolog (TELO2), Truncated

Uniprot Id

Q9Y4R8

Target Species

Human

Target Name

TELO2

Target Full Name

Telomere length regulation protein TEL2 homolog

Target Function

Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation.

Target Involvement

You-Hoover-Fong syndrome (YHFS)

Target Subcellular Location

Cytoplasm. Membrane. Nucleus. Chromosome, telomere.

Target Protein Families

TEL2 family

Target Synonyms

CLK2; hCLK2; KIAA0683; Protein clk-2 homolog; TEL2; TEL2 telomere maintenance 2 homolog; TEL2, telomere maintenance 2, homolog; telo2; TELO2_HUMAN; Telomere length regulation protein TEL2 homolog; Telomere maintenance 2

Target Background

This gene encodes a protein that functions as an S-phase checkpoint protein in the cell cycle. The protein may also play a role in DNA repair.