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| Cat.No | ACP09796 | Target Name | TNN |
|---|---|---|---|
| Target Synonyms | TNN; TNW; Tenascin-N; TN-N; Tenascin-W; TN-W | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9UQP3 |
|---|
Uniprot Id
Q9UQP3
Target Species
Human
Target Name
TNN
Target Full Name
Tenascin-N
Target Function
Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1. Involved in neurite outgrowth and cell migration in hippocampal explants. During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells. Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells.
Target Subcellular Location
Secreted, extracellular space, extracellular matrix.
Target Protein Families
Tenascin family
Target Tissue Specificity
Not detected in normal adult mammary tissues or brain but expressed in most breast tumors and brain tumors, such as glioblastomas, astrocytomas and oligodendrogliomas, tested. In brain tumors, detected around the endothelial cell layer of the clood vessel
Target Synonyms
TNN; TNW; Tenascin-N; TN-N; Tenascin-W; TN-W
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