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| Cat.No | ACP12232 | Target Name | TNS1 |
|---|---|---|---|
| Target Synonyms | matrix-remodelling associated 6; Matrix-remodelling-associated protein 6; MGC88584; MST091; MST122; MST127; MSTP091; MSTP122; MSTP127; MXRA6; TENS1_HUMAN; Tensin; Tensin-1; TNS; TNS1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9HBL0 |
|---|
Uniprot Id
Q9HBL0
Target Species
Human
Target Name
TNS1
Target Full Name
Tensin-1
Target Function
Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.
Target Subcellular Location
Cell surface. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Localized at cell periphery preferentially to fibrillar adhesions than focal adhesions. Translocates from the cell edge to cell center in an ITGB1BP1-dependent manner.
Target Tissue Specificity
Ubiquitous.
Target Synonyms
matrix-remodelling associated 6; Matrix-remodelling-associated protein 6; MGC88584; MST091; MST122; MST127; MSTP091; MSTP122; MSTP127; MXRA6; TENS1_HUMAN; Tensin; Tensin-1; TNS; TNS1
Target Background
The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms.
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