Recombinant Human Testin (TES)

Uniprot Id

Q9UGI8

Target Species

Human

Target Name

TES

Target Full Name

Testin

Target Function

Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth.

Target Subcellular Location

Cytoplasm. Cell junction, focal adhesion. Note=Detected along actin stress fibers.

Target Protein Families

Prickle / espinas / testin family

Target Tissue Specificity

Ubiquitous.

Target Synonyms

DKFZP586B2022; MGC1146; TES; TES_HUMAN; TESS 2; TESS; TESS2; Testin; Testis derived transcript (3 LIM domains); Testis derived transcript

Target Background

Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene.