Recombinant Human THAP domain-containing protein 1 (THAP1)

Uniprot Id

Q9NVV9

Target Species

Human

Target Name

THAP1

Target Full Name

THAP domain-containing protein 1

Target Function

DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.

Target Involvement

Dystonia 6, torsion (DYT6)

Target Subcellular Location

Nucleus, nucleoplasm. Nucleus, PML body.

Target Protein Families

THAP1 family

Target Tissue Specificity

Highly expressed in heart, skeletal muscle, kidney and liver. Weaker expression in brain and placenta.

Target Synonyms

4833431A01Rik; DYT6; FLJ10477; MGC33014; Nuclear proapoptotic factor; THAP 1; THAP domain containing 1; THAP domain containing apoptosis associated protein 1; THAP domain containing protein 1; THAP domain protein 1; THAP domain-containing protein 1; Thap1; THAP1_HUMAN

Target Background

The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links PAWR to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed.