Recombinant Human Thioredoxin domain-containing protein 3 (TXNDC3)

Uniprot Id

Q8N427

Target Species

Human

Target Name

NME8

Target Full Name

Thioredoxin domain-containing protein 3

Target Function

Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds.

Target Involvement

Ciliary dyskinesia, primary, 6 (CILD6)

Target Subcellular Location

Cytoplasm.

Target Protein Families

NDK family

Target Tissue Specificity

Testis-specific. Expressed only in primary spermatocytes and round spermatids.

Target Synonyms

NME8; SPTRX2; TXNDC3; Thioredoxin domain-containing protein 3; NM23-H8; NME/NM23 family member 8; Spermatid-specific thioredoxin-2; Sptrx-2

Target Background

This gene encodes a protein with an N-terminal thioredoxin domain and three C-terminal nucleoside diphosphate kinase (NDK) domains, but the NDK domains are thought to be catalytically inactive. The sea urchin ortholog of this gene encodes a component of sperm outer dynein arms, and the protein is implicated in ciliary function. Mutations in this gene are implicated in primary ciliary dyskinesia type 6.