Recombinant Human Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1 (TSTD1)

Uniprot Id

Q8NFU3

Target Species

Human

Target Name

TSTD1

Target Full Name

Thiosulfate:glutathione sulfurtransferase

Target Function

Thiosulfate:glutathione sulfurtransferase (TST) required to produce S-sulfanylglutathione (GSS(-)), a central intermediate in hydrogen sulfide metabolism. Provides the link between the first step in mammalian H(2)S metabolism performed by the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate. The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with thiosulfate as the sulfane donor.

Target Subcellular Location

Cytoplasm, perinuclear region. Note=Localized around the nuclear membranes.

Target Tissue Specificity

Highly expressed in kidney, liver and skeletal muscle. Lower levels of expression in heart, colon, thymus, spleen, placenta and lung. Weakly expressed in brain, small intestine and peripheral blood leukocytes. Expressed at high levels in the breast carcin

Target Synonyms

KAT; Putative thiosulfate sulfurtransferase KAT; Thiosulfate sulfurtransferase (rhodanese) like domain containing 1; Thiosulfate sulfurtransferase KAT putative; Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1; TSTD1; TSTD1_HUMAN