Recombinant Human THO complex subunit 2 (THOC2), Truncated

Uniprot Id

Q8NI27

Target Species

Human

Target Name

THOC2

Target Full Name

THO complex subunit 2

Target Function

Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. Required for NXF1 localization to the nuclear rim. Plays a role for proper neuronal development

Target Involvement

Mental retardation, X-linked 12 (MRX12)

Target Subcellular Location

Nucleus. Nucleus speckle.

Target Protein Families

THOC2 family

Target Tissue Specificity

Expressed in the hippocampus and the cerebral cortex.

Target Synonyms

CXorf3; DJ506G2.1; hTREX120; RP5 1189B24.5; THO complex 2; THO complex subunit 2; Tho2; THOC2; THOC2_HUMAN