Recombinant Human Tomoregulin-2 (TMEFF2), Truncated

Uniprot Id

Q9UIK5

Target Species

Human

Target Name

TMEFF2

Target Full Name

Tomoregulin-2

Target Function

May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.

Target Subcellular Location

[Isoform 1]: Membrane; Single-pass type I membrane protein.; [Isoform 2]: Membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.

Target Protein Families

Tomoregulin family

Target Tissue Specificity

Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of nor

Target Synonyms

Cancer/testis antigen family 120 member 2; CT120.2; HPP 1; HPP1; Hyperplastic polyposis protein 1; TEFF 2; TEFF2; TEFF2_HUMAN; TENB 2; TENB2; TMEFF2; Tomoregulin; Tomoregulin-2; TPEF; TR 2; TR; TR-2; Transmembrane protein containing epidermal growth factor and follistatin domains; Transmembrane protein TENB2; Transmembrane protein with EGF like and two follistatin like domains 2; Transmembrane protein with EGF-like and two follistatin-like domains

Target Background

This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants.