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| Cat.No | ACP21423 | Target Name | TRAFD1 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 2-582 | Protein Length | Full Length of Mature Protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O14545 |
|---|
Uniprot Id
O14545
Target Species
Human
Target Name
TRAFD1
Target Full Name
TRAF-type zinc finger domain-containing protein 1
Target Function
Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3.
Target Synonyms
FLN29; FLN29 gene product; Protein FLN29; TRAD1_HUMAN; TRAF type zinc finger domain containing 1; TRAF type zinc finger domain containing protein 1; TRAF-type zinc finger domain-containing protein 1; TRAFD 1; TRAFD1
Target Background
The innate immune system confers host defense against viral and microbial infection, and TRAFD1 is a negative feedback regulator that controls excessive immune responses (Sanada et al., 2008 [PubMed 18849341]).
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