Recombinant Human Trans-2,3-enoyl-CoA reductase (TECR), Truncated

Uniprot Id

Q9NZ01

Target Species

Human

Target Name

TECR

Target Full Name

Very-long-chain enoyl-CoA reductase

Target Function

Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway. Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Catalyzes the saturation step of the sphingosine 1-phosphate metabolic pathway, the conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA.

Target Involvement

Mental retardation, autosomal recessive 14 (MRT14)

Target Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Target Protein Families

Steroid 5-alpha reductase family

Target Tissue Specificity

Expressed in most tissues tested. Highly expressed in skeletal muscle.

Target Research Area

Signal Transduction

Target Synonyms

TECR; GPSN2; SC2; Very-long-chain enoyl-CoA reductase; Synaptic glycoprotein SC2; Trans-2,3-enoyl-CoA reductase; TER