Recombinant Human Trans-acting T-cell-specific transcription factor GATA-3 (GATA3)

Uniprot Id

P23771

Target Species

Human

Target Name

GATA3

Target Full Name

Trans-acting T-cell-specific transcription factor GATA-3

Target Function

Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression.

Target Involvement

Hypoparathyroidism, sensorineural deafness, and renal disease (HDR)

Target Subcellular Location

Nucleus.

Target Tissue Specificity

T-cells and endothelial cells.

Target Synonyms

GATA 3; GATA binding factor 3; GATA binding protein 3; GATA-binding factor 3; Gata3; GATA3_HUMAN; HDR; HDRS; MGC2346; MGC5199; MGC5445; Trans acting T cell specific transcription factor GATA 3; Trans-acting T-cell-specific transcription factor GATA-3

Target Background

This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia.