Recombinant Human Transcription factor 12 (TCF12)

Uniprot Id

Q99081

Target Species

Human

Target Name

TCF12

Target Full Name

Transcription factor 12

Target Function

Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').

Target Involvement

Craniosynostosis 3 (CRS3)

Target Subcellular Location

Nucleus.

Target Tissue Specificity

Expressed in several tissues and cell types including skeletal muscle, thymus, and a B-cell line.

Target Synonyms

bHLHb20; Class B basic helix-loop-helix protein 20; DNA binding protein HTF4 ; DNA-binding protein HTF4; E box binding protein; E-box-binding protein; HEB; Helix loop helix transcription factor 4; HsT17266; HTF4; HTF4_HUMAN; TCF-12; Tcf12; Transcription factor 12; Transcription factor HTF-4; Transcription factor HTF4

Target Background

The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.