Recombinant Human Transcription factor 7-like 1 (TCF7L1)

Uniprot Id

Q9HCS4

Target Species

Human

Target Name

TCF7L1

Target Full Name

Transcription factor 7-like 1

Target Function

Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. Down-regulates NQO1, leading to increased mitomycin c resistance.

Target Subcellular Location

Nucleus.

Target Protein Families

TCF/LEF family

Target Tissue Specificity

Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium.

Target Synonyms

bHLHb21; HMG box transcription factor 3; HMG box transcription factor; OTTMUSP00000023419; T cell factor 3; TCF 3; TCF-3; TCF3; Tcf7l1; TF7L1_HUMAN; Transcription factor 7 like 1 (T-cell specific, HMG-box); Transcription factor 7 like 1; Transcription factor 7-like 1

Target Background

This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence.