Recombinant Human Transcription factor E2F6 (E2F6)

Uniprot Id

O75461

Target Species

Human

Target Name

E2F6

Target Full Name

Transcription factor E2F6

Target Function

Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. Represses expression of some meiosis-specific genes, including SLC25A31/ANT4. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase.

Target Subcellular Location

Nucleus.

Target Protein Families

E2F/DP family

Target Tissue Specificity

Expressed in all tissues examined. Highest levels in placenta, skeletal muscle, heart, ovary, kidney, small intestine and spleen.

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

E2F 6; E2F binding site modulating activity protein ; E2F transcription factor 6; E2F transcription factor 6 isoform 1; E2F-6; E2F6; E2F6_HUMAN; EMA; MGC111545; Transcription factor E2F6

Target Background

This gene encodes a member of a family of transcription factors that play a crucial role in the control of the cell cycle. The protein encoded by this gene lacks the transactivation and tumor suppressor protein association domains found in other family members, and contains a modular suppression domain that functions in the inhibition of transcription. It interacts in a complex with chromatin modifying factors. There are pseudogenes for this gene on chromosomes 22 and X. Alternative splicing results in multiple transcript variants.