Recombinant Human Transcription factor ETV6 (ETV6)

Uniprot Id

P41212

Target Species

Human

Target Name

ETV6

Target Full Name

Transcription factor ETV6

Target Function

Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation.

Target Involvement

Myeloproliferative disorder chronic with eosinophilia (MPE); Leukemia, acute myelogenous (AML); Thrombocytopenia 5 (THC5)

Target Subcellular Location

Nucleus.

Target Protein Families

ETS family

Target Tissue Specificity

Ubiquitous.

Target Synonyms

ETS related protein Tel1; ETS translocation variant 6; Ets variant 6; Ets variant gene 6 (TEL oncogene); ETS-related protein Tel1; ETV 6; ETV6; ETV6_HUMAN; Tel; TEL oncogene; TEL/ABL; TEL1; TEL1 oncogene; Transcription factor ETV 6; Transcription factor ETV6

Target Background

This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.