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Recombinant Human Transcription factor Spi-B (SPIB)

ACP24500

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Specifications

Cat.No	ACP24500	Target Name	SPIB
Target Synonyms	SPI B; Spi B transcription factor; Spib; SPIB_HUMAN; Transcription factor Spi-B	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-262
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q01892

Background Information

Uniprot Id

Q01892
Target Species

Human
Target Name

SPIB
Target Full Name

Transcription factor Spi-B
Target Function

Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation.
Target Subcellular Location

[Isoform 1]: Nucleus.; [Isoform 2]: Cytoplasm.
Target Protein Families

ETS family
Target Tissue Specificity

Expressed in plasmacytoid dendritic cells (pDCs) and B-cells, not expressed in T-cells or granulocytes. May also be enriched in stem cell populations of the liver.
Target Synonyms

SPI B; Spi B transcription factor; Spib; SPIB_HUMAN; Transcription factor Spi-B

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Recombinant Human Transcription factor Spi-B (SPIB)

Specifications

Immunogen Information

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