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| Cat.No | ACP18144 | Target Name | LRRC32 |
|---|---|---|---|
| Target Synonyms | D11S833E; GARP; Garpin; Glycoprotein A repetitions predominant; Leucine rich repeat containing 32; Leucine-rich repeat-containing protein 32; LRC32_HUMAN; LRRC32 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q14392 |
|---|
Uniprot Id
Q14392
Target Species
Human
Target Name
LRRC32
Target Full Name
Transforming growth factor beta activator LRRC32
Target Function
Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta. Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3).
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cell surface.
Target Tissue Specificity
Preferentially expressed in regulatory T-cells (Tregs).
Target Synonyms
D11S833E; GARP; Garpin; Glycoprotein A repetitions predominant; Leucine rich repeat containing 32; Leucine-rich repeat-containing protein 32; LRC32_HUMAN; LRRC32
Target Background
This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies.
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