Home Products Recombinant Human Transmembrane 4 L6 family member 20 (TM4SF20), Truncated

Recombinant Human Transmembrane 4 L6 family member 20 (TM4SF20), Truncated

ACP08301

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Specifications

Cat.No	ACP08301	Target Name	TM4SF20
Target Synonyms	TM4SF20; UNQ518/PRO994; Transmembrane 4 L6 family member 20	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q53R12

Background Information

Uniprot Id

Q53R12
Target Species

Human
Target Name

TM4SF20
Target Full Name

Transmembrane 4 L6 family member 20
Target Function

Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein.
Target Involvement

Specific language impairment 5 (SLI5)
Target Subcellular Location

Membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Target Protein Families

L6 tetraspanin family
Target Tissue Specificity

Expressed in the brain, with high levels in the parietal lobe, hippocampus, pons, white matter and cerebellum.
Target Synonyms

TM4SF20; UNQ518/PRO994; Transmembrane 4 L6 family member 20

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Recombinant Human Transmembrane 4 L6 family member 20 (TM4SF20), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Transmembrane 4 L6 family member 20 (TM4SF20), Truncated Now

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