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| Cat.No | ACP05399 | Target Name | TM4SF5 |
|---|---|---|---|
| Target Synonyms | TM4SF5; Transmembrane 4 L6 family member 5; Tetraspan transmembrane protein L6H | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O14894 |
|---|
Uniprot Id
O14894
Target Species
Human
Target Name
TM4SF5
Target Full Name
Transmembrane 4 L6 family member 5
Target Function
Acts as a lysosomal membrane arginine sensor. Forms a complex with MTOR and SLC38A9 on lysosomal membranes in an arginine-regulated manner, leading to arginine efflux which enables the activation of mTORC1 which subsequently leads to RPS6KB1 and EIF4EBP1 phosphorylations. Facilitates cell cycle G1/S phase progression and the translocation of the CDK4-CCND1 complex into the nucleus. CDKN1B and RHOA/ROCK signaling activity are involved in TM4SF5-mediated acceleration of G1/S phase progression.
Target Subcellular Location
Lysosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Target Protein Families
L6 tetraspanin family
Target Tissue Specificity
Intestine. Overexpressed in pancreatic cancers.
Target Synonyms
TM4SF5; Transmembrane 4 L6 family member 5; Tetraspan transmembrane protein L6H
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