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| Cat.No | ACP08553 | Target Name | PIP4P2 |
|---|---|---|---|
| Target Synonyms | 5-bisphosphate 4-phosphatase; Type 2 PtdIns-4, 5-P2 4-Ptase II; Transmembrane protein 55A, 5-P2 4-Ptase; PtdIns-4, PIP4P2; TMEM55A; Type 2 phosphatidylinositol 4 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8N4L2 |
|---|
Uniprot Id
Q8N4L2
Target Species
Human
Target Name
PIP4P2
Target Full Name
Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
Target Function
Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate. Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4,5-bisphosphate accumulation during cup formation.
Target Subcellular Location
Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, phagosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Target Tissue Specificity
Ubiquitous.
Target Synonyms
PIP4P2; TMEM55A; Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; Type 2 PtdIns-4,5-P2 4-Ptase; PtdIns-4,5-P2 4-Ptase II; Transmembrane protein 55A
Target Background
TMEM55A catalyzes the degradation of phosphatidylinositol 4, 5-bisphosphate (PtdIns-4, 5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).
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