Recombinant Human Tribbles homolog 2 (TRIB2)

Uniprot Id

Q92519

Target Species

Human

Target Name

TRIB2

Target Full Name

Tribbles homolog 2

Target Function

Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity.

Target Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton.

Target Protein Families

Protein kinase superfamily, CAMK Ser/Thr protein kinase family, Tribbles subfamily

Target Tissue Specificity

Highly expressed in peripheral blood leukocytes.

Target Synonyms

C5FW; FLJ57420; GS3955; Hypothetical protein TRB2; TRB-2; TRB2; TRIB 2; TRIB2; TRIB2_HUMAN; Tribbles homolog 2

Target Background

This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.