Recombinant Human Trinucleotide repeat-containing gene 6A protein (TNRC6A), Truncated

Uniprot Id

Q8NDV7

Target Species

Human

Target Name

TNRC6A

Target Full Name

Trinucleotide repeat-containing gene 6A protein

Target Function

Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes.

Target Subcellular Location

Cytoplasm, P-body.

Target Protein Families

GW182 family

Target Tissue Specificity

Ubiquitous.

Target Synonyms

CAG repeat protein 26; CAGH26; DKFZp666E117; EDIE ; EMSY interactor protein; FLJ22043; Glycine tryptophan protein of 182 kDa; Glycine-tryptophan protein of 182 kDa; GW1; GW182; GW182 autoantigen; Hypothetical protein DKFZp566M143 ; KIAA1460; MGC75384; OTTHUMP00000122485; OTTHUMP00000195164; OTTHUMP00000195165; Protein GW1; TNR6A_HUMAN; TNRC 6A; TNRC6; Tnrc6a; Trinucleotide repeat containing 6A; Trinucleotide repeat containing gene 6A protein; Trinucleotide repeat-containing gene 6A protein

Target Background

This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing.