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| Cat.No | ACP17059 | Target Name | TTLL5 |
|---|---|---|---|
| Target Synonyms | KIAA0998; SRC1 and TIF2-associated modulatory protein; STAMP; TTLL5; TTLL5_HUMAN; Tubulin polyglutamylase TTLL5; Tubulin--tyrosine ligase-like protein 5 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q6EMB2 |
|---|
Uniprot Id
Q6EMB2
Target Species
Human
Target Name
TTLL5
Target Full Name
Tubulin polyglutamylase TTLL5
Target Function
Polyglutamylase which modifies tubulin, generating polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Preferentially mediates ATP-dependent initiation step of the polyglutamylation reaction over the elongation step. Preferentially modifies the alpha-tubulin tail over a beta-tail. Required for CCSAP localization to both polyglutamylated spindle and cilia microtubules. Increases the effects of transcriptional coactivator NCOA2/TIF2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction.
Target Involvement
Cone-rod dystrophy 19 (CORD19)
Target Subcellular Location
Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Nucleus. Cytoplasm.
Target Protein Families
Tubulin--tyrosine ligase family
Target Tissue Specificity
Expressed in the retina, found in the rod and cone photoreceptors (at protein level). Widely expressed with highest levels in heart and skeletal muscle and low levels in other tissues.
Target Synonyms
KIAA0998; SRC1 and TIF2-associated modulatory protein; STAMP; TTLL5; TTLL5_HUMAN; Tubulin polyglutamylase TTLL5; Tubulin--tyrosine ligase-like protein 5
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