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Recombinant Human Tubulin–tyrosine ligase (TTL)

ACP14534

Number
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High Purity LevelsPrecision and ReliabilityCustomization Options

Specifications


Cat.No ACP14534 Target NameTTL
Target SynonymsTTL; Tubulin--tyrosine ligase; TTL; EC 6.3.2.25FormLyophilized powder
Expression SystemCustom Production. Please inquire and provide the desire expression system.Expression Range1-377
Protein LengthFull length proteinPurity>85% (SDS-PAGE)
Storage Buffer5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information


Target SpeciesHumanUniprot IDQ8NG68
Background Information
  • Uniprot Id

    Q8NG68

  • Target Species

    Human

  • Target Name

    TTL

  • Target Full Name

    Tubulin--tyrosine ligase

  • Target Function

    Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.

  • Target Protein Families

    Tubulin--tyrosine ligase family

  • Target Synonyms

    TTL; Tubulin--tyrosine ligase; TTL; EC 6.3.2.25

  • Target Background

    TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).

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