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| Cat.No | ACP14534 | Target Name | TTL |
|---|---|---|---|
| Target Synonyms | TTL; Tubulin--tyrosine ligase; TTL; EC 6.3.2.25 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-377 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8NG68 |
|---|
Uniprot Id
Q8NG68
Target Species
Human
Target Name
TTL
Target Full Name
Tubulin--tyrosine ligase
Target Function
Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.
Target Protein Families
Tubulin--tyrosine ligase family
Target Synonyms
TTL; Tubulin--tyrosine ligase; TTL; EC 6.3.2.25
Target Background
TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).
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