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The region for expressing recombinant Human VASH2 contains amino acids 1-355. This VASH2 protein is expected to have a theoretical molecular weight of 56.4 kDa. This protein is generated in a e.coli-based system. Fusion of the N-terminal 6xHis-SUMO tag into the VASH2 encoding gene fragment was conducted, allowing for easier detection and purification of the VASH2 protein in subsequent stages.Human vasohibin-2 (VASH2) serves as a critical regulator in angiogenesis, influencing blood vessel formation. Its main function involves inhibiting endothelial cell proliferation and migration, exerting anti-angiogenic effects. In cardiovascular research, VASH2 contributes to understanding vascular homeostasis and potential therapeutic interventions for angiogenesis-related diseases. Additionally, VASH2 is implicated in cancer biology, where its role in angiogenesis may impact tumor growth and metastasis. Investigating VASH2 provides insights into vascular development, angiogenic disorders, and cancer progression, offering potential applications in cardiovascular medicine and oncology.
The region for expressing recombinant Human VASH2 contains amino acids 1-355. This VASH2 protein is expected to have a theoretical molecular weight of 56.4 kDa. This protein is generated in a e.coli-based system. Fusion of the N-terminal 6xHis-SUMO tag into the VASH2 encoding gene fragment was conducted, allowing for easier detection and purification of the VASH2 protein in subsequent stages.Human vasohibin-2 (VASH2) serves as a critical regulator in angiogenesis, influencing blood vessel formation. Its main function involves inhibiting endothelial cell proliferation and migration, exerting anti-angiogenic effects. In cardiovascular research, VASH2 contributes to understanding vascular homeostasis and potential therapeutic interventions for angiogenesis-related diseases. Additionally, VASH2 is implicated in cancer biology, where its role in angiogenesis may impact tumor growth and metastasis. Investigating VASH2 provides insights into vascular development, angiogenic disorders, and cancer progression, offering potential applications in cardiovascular medicine and oncology.
| Cat.No | ACP02780 | Target Name | VASH2 |
|---|---|---|---|
| Target Synonyms | FLJ12505; OTTHUMP00000035013; OTTHUMP00000035017; OTTHUMP00000228345; OTTHUMP00000228346; OTTHUMP00000228347; RP11-275G3.1; VASH2; VASH2_HUMAN; Vasohibin-2; Vasohibin-like protein | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-355aa |
| Mol Weight | 56.4kDa | Protein Length | Full length |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q86V25 |
|---|
Uniprot Id
Q86V25
Target Species
Human
Target Name
VASH2
Target Full Name
Tubulinyl-Tyr carboxypeptidase 2
Target Function
Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning. Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis. Plays a role in axon formation.
Target Subcellular Location
Cytoplasm. Secreted. Cytoplasm, cytoskeleton.
Target Protein Families
Vasohibin family
Target Research Area
Cardiovascular
Target Synonyms
FLJ12505; OTTHUMP00000035013; OTTHUMP00000035017; OTTHUMP00000228345; OTTHUMP00000228346; OTTHUMP00000228347; RP11-275G3.1; VASH2; VASH2_HUMAN; Vasohibin-2; Vasohibin-like protein
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