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The recombinant Human TNFAIP6 was expressed with the amino acid range of 18-277. This TNFAIP6 protein is expected to have a theoretical molecular weight of 33 kDa. The TNFAIP6 protein was expressed in baculovirus. The N-terminal 10xHis tag and C-terminal Myc tag was fused into the coding gene segment of TNFAIP6, making it easier to detect and purify the TNFAIP6 recombinant protein in the later stages of expression and purification.TNFAIP6 (Tumor necrosis factor-inducible gene 6 protein) is a protein of significant research interest. The primary focus of research lies in its role in inflammation and immune regulation. TNFAIP6 plays a crucial role in regulating gene expression, cell proliferation, and tumor development. Researchers investigate its expression in inflammatory conditions like rheumatoid arthritis and inflammatory bowel disease, along with its potential involvement in tumor development and treatment resistance. These studies contribute to revealing the molecular mechanisms of TNFAIP6 in the onset and progression of diseases, providing a theoretical basis for the treatment of related conditions.
The recombinant Human TNFAIP6 was expressed with the amino acid range of 18-277. This TNFAIP6 protein is expected to have a theoretical molecular weight of 33 kDa. The TNFAIP6 protein was expressed in baculovirus. The N-terminal 10xHis tag and C-terminal Myc tag was fused into the coding gene segment of TNFAIP6, making it easier to detect and purify the TNFAIP6 recombinant protein in the later stages of expression and purification.TNFAIP6 (Tumor necrosis factor-inducible gene 6 protein) is a protein of significant research interest. The primary focus of research lies in its role in inflammation and immune regulation. TNFAIP6 plays a crucial role in regulating gene expression, cell proliferation, and tumor development. Researchers investigate its expression in inflammatory conditions like rheumatoid arthritis and inflammatory bowel disease, along with its potential involvement in tumor development and treatment resistance. These studies contribute to revealing the molecular mechanisms of TNFAIP6 in the onset and progression of diseases, providing a theoretical basis for the treatment of related conditions.
| Cat.No | ACP05104 | Target Name | TNFAIP6 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | Baculovirus |
| Expression Range | 18-277aa | Mol Weight | 33 |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P98066 |
|---|
Uniprot Id
P98066
Target Species
Human
Target Name
TNFAIP6
Target Full Name
Tumor necrosis factor-inducible gene 6 protein
Target Function
Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.
Target Tissue Specificity
Found in the synovial fluid of patients with rheumatoid arthritis.
Target Research Area
Cancer
Target Synonyms
Hyaluronate binding protein; Hyaluronate-binding protein; TNF alpha induced protein 6; TNF alpha-induced protein 6; TNF stimulated gene 6 protein; TNF-stimulated gene 6 protein; TNFAIP 6; Tnfaip6; TSG 6; TSG-6; TSG6_HUMAN; Tumor necrosis factor alpha induced protein 6; Tumor necrosis factor alpha inducible protein 6; Tumor necrosis factor alpha-induced protein 6; Tumor necrosis factor inducible gene 6 protein; Tumor necrosis factor stimulated gene 6 protein; Tumor necrosis factor-inducible gene 6 protein
Target Background
The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.
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