Recombinant Human Tumor necrosis factor ligand superfamily member 8 (TNFSF8), Truncated

Uniprot Id

P32971

Target Species

Human

Target Name

TNFSF8

Target Full Name

Tumor necrosis factor ligand superfamily member 8

Target Function

Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.

Target Subcellular Location

Membrane; Single-pass type II membrane protein.

Target Protein Families

Tumor necrosis factor family

Target Synonyms

TNFSF8; CD30L; CD30LG; Tumor necrosis factor ligand superfamily member 8; CD30 ligand; CD30-L; CD antigen CD153

Target Background

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene.