Recombinant Human Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), Truncated,Biotinylated

Uniprot Id

Q02223

Target Species

Human

Target Name

TNFRSF17

Target Full Name

Tumor necrosis factor receptor superfamily member 17

Target Function

Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.

Target Involvement

A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.

Target Subcellular Location

Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Note=Perinuclear Golgi-like structures.

Target Tissue Specificity

Expressed in mature B-cells, but not in T-cells or monocytes.

Target Research Area

Cancer

Target Synonyms

BCM; BCMA; CD269; TNFRSF13A; TNFRSF17

Target Background

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.