Recombinant Human Tyrosine-protein phosphatase non-receptor type 13 (PTPN13), Truncated

Uniprot Id

Q12923

Target Species

Human

Target Name

PTPN13

Target Full Name

Tyrosine-protein phosphatase non-receptor type 13

Target Function

Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling. May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2.

Target Subcellular Location

Cytoplasm, cytoskeleton. Nucleus. Cell projection, lamellipodium.

Target Protein Families

Protein-tyrosine phosphatase family, Non-receptor class subfamily

Target Tissue Specificity

Expressed in keratinocytes (at protein level). Present in most tissues with the exception of the liver and skeletal muscle. Most abundant in lung, kidney and fetal brain.

Target Synonyms

PTPN13; PNP1; PTP1E; PTPL1; Tyrosine-protein phosphatase non-receptor type 13; EC 3.1.3.48; Fas-associated protein-tyrosine phosphatase 1; FAP-1; PTP-BAS; Protein-tyrosine phosphatase 1E; PTP-E1; hPTPE1; Protein-tyrosine phosphatase PTPL1

Target Background

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.