Recombinant Human Ubiquitin carboxyl-terminal hydrolase 21 (USP21), Truncated

Cat.No	ACP00527	Target Name	USP21
Target Synonyms	Deubiquitinating enzyme 21;Ubiquitin thioesterase 21;Ubiquitin-specific-processing protease 21	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	200-565aa
Mol Weight	48.3 kDa	Protein Length	Partial
Purity	Greater than 85% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP00527

Target Name

USP21

Target Synonyms

Deubiquitinating enzyme 21;Ubiquitin thioesterase 21;Ubiquitin-specific-processing protease 21

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

200-565aa

Mol Weight

48.3 kDa

Protein Length

Partial

Purity

Greater than 85% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9UK80

Background Information

Uniprot Id

Q9UK80
Target Species

Human
Target Name

USP21
Target Full Name

Ubiquitin carboxyl-terminal hydrolase 21
Target Function

Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates. Deubiquitinates BAZ2A/TIP5 leading to its stabilization.
Target Subcellular Location

Cytoplasm. Nucleus.
Target Protein Families

Peptidase C19 family, USP21 subfamily
Target Tissue Specificity

Highly expressed in heart, pancreas and skeletal muscle. Also expressed in brain, placenta, liver and kidney, and at very low level in lung.
Target Research Area

Cell Biology
Target Synonyms

Deubiquitinating enzyme 21; deubiquitinating enzyme 23; EC 3.1.2.15; ESTM28; MGC3394; NEDD8-specific protease; Ubiquitin carboxyl terminal hydrolase 21; ubiquitin carboxyl terminal hydrolase 23; Ubiquitin carboxyl-terminal hydrolase 21; ubiquitin specific peptidase 21; Ubiquitin specific processing protease 21; ubiquitin specific protease 16; ubiquitin specific protease 21; ubiquitin specific protease 23; Ubiquitin thioesterase 21; Ubiquitin thiolesterase 21; ubiquitin thiolesterase 23; ubiquitin-specific protease 23, formerly; Ubiquitin-specific-processing protease 21; UBP21_HUMAN; USP16; Usp21; USP23; USP23, formerly; W53272
Target Background

This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Recombinant Human Ubiquitin carboxyl-terminal hydrolase 21 (USP21), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Ubiquitin carboxyl-terminal hydrolase 21 (USP21), Truncated Now

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