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Recombinant Human Ubiquitin carboxyl-terminal hydrolase 3 (USP3)

ACP09664

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Specifications

Cat.No	ACP09664	Target Name	USP3
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-520	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q9Y6I4

Background Information

Uniprot Id

Q9Y6I4
Target Species

Human
Target Name

USP3
Target Full Name

Ubiquitin carboxyl-terminal hydrolase 3
Target Function

Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin.
Target Subcellular Location

Nucleus. Note=Localizes preferentially with monoubiquitinated H2A to chromatin.
Target Protein Families

Peptidase C19 family, USP3 subfamily
Target Tissue Specificity

Expressed in all tissues examined, with strongest expression in pancreas.
Target Synonyms

Deubiquitinating enzyme 3; EC 3.1.2.15; SIH003; Ubiquitin carboxyl-terminal hydrolase 3; Ubiquitin specific peptidase 3; Ubiquitin specific processing protease 3; Ubiquitin Specific Protease 3; Ubiquitin thioesterase 3; Ubiquitin thiolesterase 3; Ubiquitin-specific-processing protease 3; UBP; UBP3_HUMAN; Usp3
Target Background

Enables histone binding activity and thiol-dependent deubiquitinase. Involved in several processes, including DNA repair; histone deubiquitination; and regulation of protein stability. Located in several cellular components, including Flemming body; cytoplasmic ribonucleoprotein granule; and nucleoplasm.

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Recombinant Human Ubiquitin carboxyl-terminal hydrolase 3 (USP3)

Specifications

Immunogen Information

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