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| Cat.No | ACP18807 | Target Name | B3GNT3 |
|---|---|---|---|
| Target Synonyms | 3-galactosyl-O-glycosyl-glycoprotein beta-1, 3-galactosyltransferase 8, 3-galactosyltransferase 8; Beta-1, 3-galactosyltransferase 8; UDP-GlcNAc:betaGal beta-1, 3-GalTase 8; Beta3Gal-T8; Beta3GalT8; b3Gal-T8; Beta-3-Gx-T8; Core 1 extending beta-1, 3-Gn-T3; Beta-1, 3-N-acetylglucosaminyltransferase 3; Beta3Gn-T3; UDP-galactose:beta-N-acetylglucosamine beta-1, 3-N-acetylglucosaminyltransferase 3; BGnT-3; Beta-1, 3-N-acetylglucosaminyltransferase 3; EC 2.4.1.149; Beta-1, 3-N-acetylglucosaminyltransferase; Core1-beta3GlcNAcT; Transmembrane protein 3; UDP-Gal:beta-GlcNAc beta-1, 3-N-acetylglucosaminyltransferase; EC 2.4.1.146; Beta-1, B3GNT3; B3GALT8; TMEM3; UNQ637/PRO1266N-acetyllactosaminide beta-1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9Y2A9 |
|---|
Uniprot Id
Q9Y2A9
Target Species
Human
Target Name
B3GNT3
Target Full Name
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3
Target Function
Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides. Also acts as a core1-1,3-N-acetylglucosaminyltransferase (Core1-beta3GlcNAcT) to form the 6-sulfo sialyl Lewis x on extended core1 O-glycans.
Target Subcellular Location
Golgi apparatus membrane; Single-pass type II membrane protein.
Target Protein Families
Glycosyltransferase 31 family
Target Tissue Specificity
Expressed in colon, jejunum, stomach, esophagus, placenta and trachea.
Target Synonyms
B3GNT3; B3GALT8; TMEM3; UNQ637/PRO1266N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3; EC 2.4.1.149; Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase; EC 2.4.1.146; Beta-1,3-galactosyltransferase 8; Beta-1,3-GalTase 8; Beta3Gal-T8; Beta3GalT8; b3Gal-T8; Beta-3-Gx-T8; Core 1 extending beta-1,3-N-acetylglucosaminyltransferase; Core1-beta3GlcNAcT; Transmembrane protein 3; UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 8; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3; BGnT-3; Beta-1,3-Gn-T3; Beta-1,3-N-acetylglucosaminyltransferase 3; Beta3Gn-T3; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 8
Target Background
This gene encodes a member of the beta-1, 3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein and contains a signal anchor that is not cleaved. It prefers the substrates of lacto-N-tetraose and lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains and the biosynthesis of the backbone structure of dimeric sialyl Lewis a. It plays dominant roles in L-selectin ligand biosynthesis, lymphocyte homing and lymphocyte trafficking.
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