Recombinant Human UDP-glucuronosyltransferase 1A8 (UGT1A8)

Cat.No	ACP02198	Target Name	UGT1A8
Target Synonyms	(UGT1A8)(UDP-glucuronosyltransferase 1-8)(UDPGT 1-8)(UGT1*8)(UGT1-08)(UGT1.8)(UDP-glucuronosyltransferase 1-H)(UGT-1H)(UGT1H)	Form	Liquid or Lyophilized powder
Expression System	in vitro E.coli expression system	Expression Range	26-530aa
Mol Weight	59.9 kDa	Protein Length	Full Length of Mature Protein
Purity	Greater than 85% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP02198

Target Name

UGT1A8

Target Synonyms

(UGT1A8)(UDP-glucuronosyltransferase 1-8)(UDPGT 1-8)(UGT1*8)(UGT1-08)(UGT1.8)(UDP-glucuronosyltransferase 1-H)(UGT-1H)(UGT1H)

Form

Liquid or Lyophilized powder

Expression System

in vitro E.coli expression system

Expression Range

26-530aa

Mol Weight

59.9 kDa

Protein Length

Full Length of Mature Protein

Purity

Greater than 85% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9HAW9

Background Information

Uniprot Id

Q9HAW9
Target Species

Human
Target Name

UGT1A8
Target Full Name

UDP-glucuronosyltransferase 1A8
Target Function

UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens and estrogens. Produces dihydrotestosterone (DHT) diglucuronide from the DHT after two subsequent glucoronidation steps. Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II. Also metabolizes mycophenolate, an immunosuppressive agent.; Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1
Target Subcellular Location

Endoplasmic reticulum membrane; Single-pass membrane protein.
Target Protein Families

UDP-glycosyltransferase family
Target Tissue Specificity

[Isoform 1]: Expressed in kidney, colon and small intestine. Not expressed in liver.; [Isoform 2]: Expressed in liver, kidney, colon and small intestine.
Target Research Area

Metabolism
Target Synonyms

UGT1A8; GNT1; UGT1; UDP-glucuronosyltransferase 1A8; UGT1A8; UDP-glucuronosyltransferase 1-8; UDPGT 1-8; UGT1*8; UGT1-08; UGT1.8; UDP-glucuronosyltransferase 1-H; UGT-1H; UGT1H

Recombinant Human UDP-glucuronosyltransferase 1A8 (UGT1A8)

Specifications

Immunogen Information

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