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| Cat.No | ACP17560 | Target Name | MAJIN |
|---|---|---|---|
| Target Synonyms | MAJIN; C11orf85Membrane-anchored junction protein | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-216 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q3KP22 |
|---|
Uniprot Id
Q3KP22
Target Species
Human
Target Name
MAJIN
Target Full Name
Membrane-anchored junction protein
Target Function
Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane.
Target Subcellular Location
Nucleus inner membrane; Single-pass membrane protein. Chromosome, telomere.
Target Protein Families
MAJIN family
Target Synonyms
MAJIN; C11orf85Membrane-anchored junction protein
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