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| Cat.No | ACP11797 | Target Name | CXorf21 |
|---|---|---|---|
| Target Synonyms | CXorf21Protein CXorf21 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-301 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9HAI6 |
|---|
Uniprot Id
Q9HAI6
Target Species
Human
Target Name
CXORF21
Target Full Name
TLR adapter interacting with SLC15A4 on the lysosome
Target Function
Innate immune adapter that mediates the recruitment and activation of IRF5 downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Following recruitment to endolysosome by SLC15A4 downstream of TLR7, TLR8 and TLR9, specifically recruits IRF5 transcription factor via its pLxIS motif, leading to IRF5 activation and subsequent expression of type I interferons. Plays a role in the regulation of endolysosomal pH in immune cells such as B-cells, dendritic cells and monocytes.
Target Subcellular Location
Lysosome membrane. Endosome membrane. Nucleus. Cytoplasm.
Target Tissue Specificity
Highly expressed in immune cell types such as B-cells, neutrophils, dendritic cells and monocytes, the expression levels are two-three-fold higher in female cells compared to male cells (at protein level). Expressed at low levels in T-cells and NK cells.
Target Synonyms
CXorf21Protein CXorf21
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