Recombinant Human Uroplakin-3a (UPK3A), Truncated

Uniprot Id

O75631

Target Species

Human

Target Name

UPK3A

Target Full Name

Uroplakin-3a

Target Function

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence.

Target Involvement

Mutations in UPK3A have been detected in patients with renal adyplasia suggesting a possible involvement of this gene in kidney and urinary tract anomalies.

Target Subcellular Location

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Target Protein Families

Uroplakin-3 family

Target Tissue Specificity

Expressed in ureter.

Target Synonyms

UPK3A; UPK3; Uroplakin-3a; UP3a; Uroplakin III; UPIII

Target Background

This gene encodes a member of the uroplakin family, a group of transmembrane proteins that form complexes on the apical surface of the bladder epithelium. Mutations in this gene may be associated with renal adysplasia. Alternatively spliced transcript variants have been described.