Recombinant Human V-type proton ATPase 116 kDa subunit a isoform 1 (ATP6V0A1), Truncated

Uniprot Id

Q93050

Target Species

Human

Target Name

ATP6V0A1

Target Full Name

V-type proton ATPase 116 kDa subunit a 1

Target Function

Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle.

Target Subcellular Location

Cytoplasmic vesicle membrane; Multi-pass membrane protein. Melanosome. Note=Coated vesicle. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Target Protein Families

V-ATPase 116 kDa subunit family

Target Synonyms

a1; ATP6N1; ATP6N1A; ATP6V0A1; ATPase H+ transporting lysosomal (vacuolar proton pump) non catalytic accessory protein 1A (110/116kD); ATPase H+ transporting lysosomal non catalytic accessory protein 1 (110/116kD); ATPase H+ transporting lysosomal V0 subunit a1; ATPase H+ transporting V0 subunit a1; ATPase, H+ transporting, lysosomal, noncatalytic accessory protein 1A; Clathrin coated vesicle/synaptic vesicle proton pump 116 kDa subunit; Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit; DKFZp781J1951; H(+) transporting two sector ATPase 116 kDa accessory protein A1; Stv1; V ATPase 116 kDa; V ATPase 116 kDa isoform a1; V type proton ATPase 116 kDa subunit a; V type proton ATPase 116 kDa subunit a isoform 1; V-ATPase 116 kDa isoform a1; V-type proton ATPase 116 kDa subunit a isoform 1; Vacuolar adenosine triphosphatase subunit Ac116; Vacuolar proton pump subunit 1; Vacuolar proton pump, subunit 1; Vacuolar proton translocating ATPase 116 kDa subunit A; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1; Vacuolar type H(+) ATPase 115 kDa subunit; Vph1; VPP1; VPP1_HUMAN

Target Background

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene.