Recombinant Human Vacuolar protein sorting-associated protein 33B (VPS33B)

Cat.No	ACP10671	Target Name	VPS33B
Target Synonyms	VPS33BVacuolar protein sorting-associated protein 33B; hVPS33B	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	2-617
Protein Length	Full Length of Mature Protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP10671

Target Name

VPS33B

Target Synonyms

VPS33BVacuolar protein sorting-associated protein 33B; hVPS33B

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

2-617

Protein Length

Full Length of Mature Protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9H267

Background Information

Uniprot Id

Q9H267
Target Species

Human
Target Name

VPS33B
Target Full Name

Vacuolar protein sorting-associated protein 33B
Target Function

May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages. Proposed to be involved in endosomal maturation implicating VIPAS39. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical recycling pathway and in the maintenance of the apical-basolateral polarity. Seems to be involved in the sorting of specific cargos from the trans-Golgi network to alpha-granule-destined multivesicular bodies (MVBs) promoting MVBs maturation in megakaryocytes.
Target Involvement

Arthrogryposis, renal dysfunction and cholestasis syndrome 1 (ARCS1)
Target Subcellular Location

Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Recycling endosome.
Target Protein Families

STXBP/unc-18/SEC1 family
Target Tissue Specificity

Ubiquitous; highly expressed in testis and low expression in the lung.
Target Synonyms

VPS33BVacuolar protein sorting-associated protein 33B; hVPS33B
Target Background

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C vacuolar protein sorting proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Mutations in this gene are associated with arthrogryposis-renal dysfunction-cholestasis syndrome. Alternative splicing results in multiple transcript variants.

Recombinant Human Vacuolar protein sorting-associated protein 33B (VPS33B)

Specifications

Immunogen Information

Inquire Recombinant Human Vacuolar protein sorting-associated protein 33B (VPS33B) Now

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