Recombinant Human Vacuolar protein sorting-associated protein 37A (VPS37A)

Uniprot Id

Q8NEZ2

Target Species

Human

Target Name

VPS37A

Target Full Name

Vacuolar protein sorting-associated protein 37A

Target Function

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.

Target Involvement

Spastic paraplegia 53, autosomal recessive (SPG53)

Target Subcellular Location

Late endosome membrane; Peripheral membrane protein. Nucleus.

Target Protein Families

VPS37 family

Target Tissue Specificity

Widely expressed. Examined tissues include heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. More abundant in liver. Strongly decreased or undetected in hepatomas.

Target Synonyms

VPS37A; HCRP1; Vacuolar protein sorting-associated protein 37A; hVps37A; ESCRT-I complex subunit VPS37A; Hepatocellular carcinoma-related protein 1

Target Background

This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene.