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| Cat.No | ACP16645 | Target Name | VARS2 |
|---|---|---|---|
| Target Synonyms | COXPD20; mitochondrial; SYVM_HUMAN; Valine--tRNA ligase; ValRS; Valyl tRNA synthetase 2 mitochondrial; Valyl-tRNA synthetase; Valyl-tRNA synthetase-like; Vars2; VARS2L; VARSL | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q5ST30 |
|---|
Uniprot Id
Q5ST30
Target Species
Human
Target Name
VARS2
Target Full Name
Valine--tRNA ligase, mitochondrial
Target Involvement
Combined oxidative phosphorylation deficiency 20 (COXPD20)
Target Subcellular Location
Mitochondrion.
Target Protein Families
Class-I aminoacyl-tRNA synthetase family
Target Synonyms
COXPD20; mitochondrial; SYVM_HUMAN; Valine--tRNA ligase; ValRS; Valyl tRNA synthetase 2 mitochondrial; Valyl-tRNA synthetase; Valyl-tRNA synthetase-like; Vars2; VARS2L; VARSL
Target Background
This gene encodes a mitochondrial aminoacyl-tRNA synthetase, which catalyzes the attachment of valine to tRNA(Val) for mitochondrial translation. Mutations in this gene cause combined oxidative phosphorylation deficiency-20, and are also associated with early-onset mitochondrial encephalopathies. Alternative splicing of this gene results in multiple transcript variants.
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