Recombinant Human Vang-like protein 2 (VANGL2), Truncated

Uniprot Id

Q9ULK5

Target Species

Human

Target Name

VANGL2

Target Full Name

Vang-like protein 2

Target Function

Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear.

Target Involvement

Neural tube defects (NTD)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

Vang family

Target Synonyms

VANGL2; KIAA1215; STB1; Vang-like protein 2; Loop-tail protein 1 homolog; Strabismus 1; Van Gogh-like protein 2

Target Background

The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate.