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Introducing our Recombinant Human VCL protein, expertly designed for use in cell adhesion research. This partial Vinculin (Metavinculin) protein is expressed in an E. coli system and spans the 2-235aa region, ensuring optimal functionality for your experiments. Featuring an N-terminal GST-tag, this high-quality protein enables efficient purification and detection processes. With a purity greater than 90% as determined by SDS-PAGE, our Recombinant Human VCL protein is available in both liquid and lyophilized powder forms to accommodate your specific research requirements. Trust in our precision-engineered VCL protein to deliver consistent, reliable results for your cell adhesion studies.
Introducing our Recombinant Human VCL protein, expertly designed for use in cell adhesion research. This partial Vinculin (Metavinculin) protein is expressed in an E. coli system and spans the 2-235aa region, ensuring optimal functionality for your experiments.
Featuring an N-terminal GST-tag, this high-quality protein enables efficient purification and detection processes. With a purity greater than 90% as determined by SDS-PAGE, our Recombinant Human VCL protein is available in both liquid and lyophilized powder forms to accommodate your specific research requirements. Trust in our precision-engineered VCL protein to deliver consistent, reliable results for your cell adhesion studies.
| Cat.No | ACP02280 | Target Name | VCL |
|---|---|---|---|
| Target Synonyms | CMD1W; CMH15; Epididymis luminal protein 114; HEL114; Metavinculin; MV; MVCL; OTTHUMP00000019861; OTTHUMP00000019862; VCL; VINC; VINC_HUMAN; Vinculin | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 2-235aa |
| Mol Weight | 53.0kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P18206 |
|---|
Uniprot Id
P18206
Target Species
Human
Target Name
VCL
Target Full Name
Vinculin
Target Function
Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
Target Involvement
Cardiomyopathy, dilated 1W (CMD1W); Cardiomyopathy, familial hypertrophic 15 (CMH15)
Target Subcellular Location
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, adherens junction. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side.
Target Protein Families
Vinculin/alpha-catenin family
Target Tissue Specificity
Metavinculin is muscle-specific.
Target Research Area
Cell Adhesion
Target Synonyms
CMD1W; CMH15; Epididymis luminal protein 114; HEL114; Metavinculin; MV; MVCL; OTTHUMP00000019861; OTTHUMP00000019862; VCL; VINC; VINC_HUMAN; Vinculin
Target Background
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
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