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| Cat.No | ACP14332 | Target Name | WDR24 |
|---|---|---|---|
| Target Synonyms | C16orf21; DKFZp434F054; JFP7; LA16c-313D11.2; WD repeat-containing protein 24; wdr24; WDR24_HUMAN | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q96S15 |
|---|
Uniprot Id
Q96S15
Target Species
Human
Target Name
WDR24
Target Full Name
GATOR2 complex protein WDR24
Target Function
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1. In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux.
Target Subcellular Location
Lysosome membrane.
Target Protein Families
WD repeat WDR24 family
Target Synonyms
C16orf21; DKFZp434F054; JFP7; LA16c-313D11.2; WD repeat-containing protein 24; wdr24; WDR24_HUMAN
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