Recombinant Human WD repeat-containing protein 34 (WDR34)

Uniprot Id

Q96EX3

Target Species

Human

Target Name

DYNC2I2

Target Full Name

Cytoplasmic dynein 2 intermediate chain 2

Target Function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system. DYNC2I2 plays a major role in retrograde ciliary protein trafficking and in ciliogenesis. Required also to maintain a functional transition zone.; Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation.

Target Involvement

Short-rib thoracic dysplasia 11 with or without polydactyly (SRTD11)

Target Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium. Cell projection, filopodium.

Target Tissue Specificity

Expressed in several cell lines (at protein level).

Target Synonyms

bA216B9.3; DIC5; MGC20486; OTTHUMP00000022282; RP11 216B9.5; WD repeat containing protein 34; WD repeat domain 34; WD repeat-containing protein 34; WDR 34; Wdr34; WDR34_HUMAN