Recombinant Human WD repeat domain phosphoinositide-interacting protein 3 (WDR45L)

Uniprot Id

Q5MNZ6

Target Species

Human

Target Name

WDR45B

Target Full Name

WD repeat domain phosphoinositide-interacting protein 3

Target Function

Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P), and other phosphoinositides including PtdIns(3,5)P2, forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2. In the cellular response to starvation, may also function together with the TSC1-TSC2 complex and RB1CC1 in the inhibition of the mTORC1 signaling pathway.

Target Subcellular Location

Preautophagosomal structure. Lysosome.

Target Protein Families

WD repeat SVP1 family

Target Tissue Specificity

Ubiquitously expressed. Highly expressed in heart, skeletal muscle and pancreas. Up-regulated in a variety of tumor tissues including ovarian and uterine cancers.

Target Synonyms

WD repeat domain phosphoinositide-interacting protein 3; WD repeat protein 45 like; WD repeat-containing protein 45-like; WDR4 like; WDR45 like protein; WDR45-like protein; wdr45l; WIPI 3; WIPI-3; WIPI3; WIPI3_HUMAN; WIPI49 like protein; WIPI49-like protein