Recombinant Human WD repeat domain phosphoinositide-interacting protein 4 (WDR45)

Uniprot Id

Q9Y484

Target Species

Human

Target Name

WDR45

Target Full Name

WD repeat domain phosphoinositide-interacting protein 4

Target Function

Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes. Together with WIPI1, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes. Probably recruited to membranes through its PtdIns3P activity.

Target Involvement

Neurodegeneration with brain iron accumulation 5 (NBIA5)

Target Subcellular Location

Preautophagosomal structure. Cytoplasm.

Target Protein Families

WD repeat SVP1 family

Target Tissue Specificity

Ubiquitously expressed, with high expression in skeletal muscle and heart. Weakly expressed in liver and placenta. Expression is down-regulated in pancreatic and in kidney tumors.

Target Research Area

Cell Biology

Target Synonyms

WDR45; WDRX1; WDRXI4; WIPI4; JM5; WD repeat domain phosphoinositide-interacting protein 4; WIPI-4; WD repeat-containing protein 45

Target Background

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined.